If you're playing against a person that you know is playing Chaos Orb (which would be an incredibly rare sight given that the card is not only rare and expensive, but is also illegal in every format except for non-sanctioned games), then you could possibly take advantage of these quirks
Uro, Titan of Nature's Wrath Ive already praised the design behind the titans from Theros: Beyond Death
That being said future printings might buff Wrenn and Six since its potential for being a land recurring threat are high, but for what Modern is now I dont really believe W6 deserves the second place, or to rephrase it: Definitely not in comparison to Shardless Agent
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Using your two-mana spell to take out a three-mana target always leaves you wondering if you could have waited and taken out a dragon without worrying that the dragon will be the wrong color